HDAC7 and immunometabolic

I am very happy to share the work of Kaustav ds Gupta and The Sweet Group on the role of HDAC7 in immunometabolic just published in PNAS USA. It's always a pleasure to work with these talented scientists. This work identified new pathways, controlled by HDAC7, for could be targeted for host-directed therapies in inflammatory or infectious diseases.

"The significance of this study lies in the identification of antiinflammatory and antimicrobial activities of the metabolite D-ribulose-5-phosphate, as well as avenues for selectively manipulating host defense versus inflammation."

HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages.

Das Gupta K, Ramnath D, von Pein JB, Curson JEB, Wang Y, Abrol R, Kakkanat A, Moradi SV, Gunther KS, Murthy AMV, Stocks CJ, Kapetanovic R, Reid RC, Iyer A, Ilka ZC, Nauseef WM, Plan M, Luo L, Stow JL, Schroder K, Karunakaran D, Alexandrov K, Shakespear MR, Schembri MA, Fairlie DP, Sweet MJ.Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2212813120. doi: 10.1073/pnas.2212813120. Epub 2023 Jan 17.PMID: 36649417